Genetic Engineering & Biotechnology

    Faculty Profile

    Dr Mohammad Jakir Hosen

    Professor

    Contact Information:

    • Office Address: Department of Genetic Engineering and Biotechnology, Shahajalal University of Science and Technology, Academic building-E, Room 214, Kumargaon, Sylhet-3114, Bangladesh.
    • Phone: Tel: 88-0821-714479-Extn. 2614, Mobile: 088-01777195857
    • Email: jakir-gen@sust.edu, jakir_gen@yahoo.com

    Biography:

    Dr. Mohammad Jakir Hosen is a Geneticist and Biotechnologist, with a Ph.D. in Medical Genetics from Ghent University, Belgium. Currently, he is working as a Professor of the Dept. of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Bangladesh. At Ghent University, his work with Prof. Dr. Olivier Vanakker and Prof. Dr. Anne De Paepe led to a significant understanding of the pathomechanism of pseudoxanthoma elasticum, a genetic disease that causes ectopic mineralization of elastic fibers in some specific tissues. At Shahjalal University, Dr. Jakir and his lab collaborate with several other in-house, national, and international groups to illustrate and understand the genetic, molecular, and physiological factors responsible for rare and common genetic disorders present in Bangladesh. He also studies the public health and epidemiological backgrounds of some infectious diseases including chikungunya, dengue, and COVID19. His lab facilitates a semi-automated zebrafish and drosophila facility for toxicological assessment of heavy metals during early embryonic development. As of 2020, Dr. Hosen has authored over 40 peer-reviewed research articles, many expert reviews, and a book chapter. Dr. Hosen is currently working to develop an efficient, dynamic, and cheap model for genetic testing and counseling implementation in the context of low and lower-middle-income countries, like Bangladesh.

    https://orcid.org/0000-0001-6444-0214
    https://scholar.google.co.id/citations?user=U4Ic8t4AAAAJ&hl=en&authuser=1&oi=ao
    https://www.researchgate.net/profile/Mohammad-Hosen-2

    Education:

    • PhD in Medical Sciences (Medical Genetics), Ghent University, 9000 Ghent, Belgium
    • European Masters of Science in Nematology, Ghent University, 9000 Ghent, Belgium
    • B.Sc in Biotechnology and Genetic Engineering, Khulna University, Khulna 9208, Bangladesh
    • Certificate in Laboratory Animal Science (FELASA-C), Ghent University, 9000 Ghent, Belgium

    Research Interests:

    • Genetic Disease
    • Public Health
    • Disease Outbreak
    • Bioinformatics
    • Plant parasite

    Active Research Project

    1. Genetic Disease: Pseudoxanthoma Elasticum, Beta-thalassemia, Autism, Peripheral Arterial Disease, Diabetes, Cystic Fibrosis, Cardiovascular diseases
    2. Public Health: Obesity, cancer, food and nutrition status, consanguineous marriage, internet use and health problem
    3. Environmental Biotechnology: Teratogen, impact of food additive, medical waste management, Environment related disability
    4. Infectious disease: Dengue, Chikungunya, COVID-19
    5. Bioinformatics: Drug design
    6. Plant-pathogen interaction: Status of M. graminicola and R. similis infestation in rice and banana respectively

    Previous Research Project

    1. Novel insights in the pathogenesis of pseudoxanthoma elasticum
    2. Study hormonal signaling pathway of rice-nematode interaction
    3. Impact of consanguineous marriage in Bangladeshi population
    4. In silico study of GLUT10, TAPT1, LOX1, GGCX, ENPP1
    5. Molecular screening of Progeria
    6. Prevalence of M. graminicola and R. similis in rice and banana respectively
    7. Epidemiology and pathogenesis of dengue, chikungunya and nCOV2

    External Affiliations:

    • National Young Academy of Bangladesh
    • Alumni, EUMAINE, Ghent University, 9000 Ghent, Belgium
    • Alumni, Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    • Belgium Society of Biochemistry and Molecular Biology
    • American Society of Human Genetics
    • American Society of Microbiology
    • PXE international
    • Bangladesh Association of Biotechnology Graduates
    • Advisor: Science Arena
    • Advisor: Community of Biotechnology

    Awards & Recognition:

    • BAS-TWAS Young Scientist Award-2018
    • 4th Batch of Regional Course on Good Clinical Laboratory Practice at GADJAH MADA UNIVERSITY, Indonesia. REGIONAL TRAINING CENTER FOR HEALTH RESEARCH SUPPORTED BY WHO-TDR
    • Khulna University Merit Scholarship for the academic years 1999-2002
    • FWO travel grant to participate ASHG meeting 2014, October 18-22, San Diego, California, USA
    • Zebrafish Meeting Financial Aid Award, 10th International Zebrafish Genetics and Development meeting-2012, June 20-24, 2012- Madison, Wisconsin, USA
    • Young Investigator Award: 12th International Congress of Human Genetics-2011, Montreal, Canada
    • Sweden-Bangladesh Trust Fund travel grant for the academic session 2009-2010
    • EDIT (European Distributed Institute of Taxonomy) Summer School 2009 grant by the European Union, From field to Web- studying biodiversity with the taxonomists toolbox, Muranska Planina National Park, Slovakia
    • Erasmus Mundus Scholarship by European Commission for 2 years European Masters in Nematology (EUMAINE) for 2008-2010
    • PhD Studentship, Department of Pediatrics and Medical Genetics, Ghent University, Belgium for the years 2010-2015

    Journal Publications

    1. Tabassum T, Araf Y, Moin AT, Rahaman TI, Mohammad Jakir Hosen. COVID-19-associated-mucormycosis: possible role of free iron uptake and immunosuppression. Mol Biol Rep. 2021 Oct 28. doi: 10.1007/s11033-021-06862-4.
    2. Fariya Akter, Yusha Araf, Mohammad Jakir Hosen. Corticosteroids for COVID-19: worth it or not? Mol Biol Rep . 2021 Oct 13. doi: 10.1007/s11033-021-06793-0
    3. Tabassum T, Rahman A, Araf Y, Ullah MA, Hosen MJ. Prospective selected biomarkers in COVID-19 diagnosis and treatment. Biomark Med. 2021 Sep 20. doi: 10.2217/bmm-2021-0038. Online ahead of print. PMID: 34538093
    4. Mohammad Jakir Hosen, Shrabony Akter Eva, Mohammad Mahfujur Rahman, Md. Ibrahim, Ummay Fateema Lira, Asma Binte Hossain, Manik Chandra Shill, Md. Jamal Uddin. Health impacts of excessive use of Facebook among university students in Bangladesh. Heliyon 7 (2021) e07271
    5. Ali N, Fariha KA, Islam F, Mishu MA, Mohanto NC, Hosen MJ, Hossain K. Exposure to air pollution and COVID-19 severity: a review of current insights, management and challenges. Integr Environ Assess Manag.
    6. Ahsab Rahman, Tahani Tabassum, Yusha Araf, Abdullah Al Nahid, Md Asad Ullah, Mohammad Jakir Hosen*. Silent hypoxia in COVID-19: pathomechanism and possible management strategy. Mol Biol Rep . 2021 Apr 23. doi: 10.1007/s11033-021-06358-1
    7. Genetic counseling in the context of Bangladesh: current scenario, challenges, and a framework for genetic service implementation. Mohammad Jakir Hosen, Anwar S, Taslem Mourosi J, Chakraborty S, Miah MF, Vanakker OM. Orphanet J Rare Dis. 2021 Apr 9;16(1):168. doi: 10.1186/s13023-021-01804-6.
    8. Assessment of the role of zinc in the prevention of COVID-19 infections and mortality: A retrospective study in the Asian and European population. Ali N, Fariha KA, Islam F, Mohanto NC, Ahmad I, Hosen MJ, Ahmed S. J Med Virol. 2021 Mar 12. doi: 10.1002/jmv.26932.
    9. Rahatul Islam, Md Sorwer Alam Parvez, Saeed Anwar, Mohammad Jakir Hosen. Delineating blueprint of an epitope-based peptide vaccine against the multiple serovars of dengue virus: A hierarchical reverse vaccinology approach. Informatics in Medicine Unlocked 20:100430
    10. Skeletal dysplasia: a series of five cases of Bangladesh demonstrating classical achondroplasia By: Tohura Tahsin1, Nazifa Zabeen1, Nishat Salsabil1, Sumaiya Rahman1, Ruksana Begum1, Raidah Fairuze Niti, Jarin Tasnim, Mohammad Jakir Hosen Key Words: Achondroplasia, RAMP disorder, Cataract, Foot abnormality. Int. J. Biosci. 16(3), 384-388, March 2020. DOI: http://dx.doi.org/10.12692/ijb/16.3.384-388
    11. Comprehensive in silico Study of GLUT10: Prediction of Possible Substrate Binding Sites and Interacting Molecules. Hosen MJ, Hasan M, Chakraborty S, Abir RA, Zubaer A, Coucke P. Curr Pharm Biotechnol. 2020;21(2):117-130. doi: 10.2174/1389201020666190613152030. PMID: 31203799
    12. Prediction of Epitope-Based Peptide Vaccine Against the Chikungunya Virus by Immuno-informatics Approach. Anwar S, Mourosi JT, Khan MF, Hosen MJ. Curr Pharm Biotechnol. 2020;21(4):325-340. doi: 10.2174/1389201020666191112161743. PMID: 31721709
    13. Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model. Kabir T, Anwar S, Taslem Mourosi J, Hossain J, Rabbane MG, Rahman MM, Tahsin T, Hasan MN, Shill MC, Hosen MJ. Toxicol Rep. 2020 Jan 11;7:155-161. doi: 10.1016/j.toxrep.2019.12.009. eCollection 2020. PMID: 31993334
    14. Chikungunya outbreak in Bangladesh (2017): Clinical and hematological findings. Anwar S, Taslem Mourosi J, Khan MF, Ullah MO, Vanakker OM, Hosen MJ. PLoS Negl Trop Dis. 2020 Feb 24;14(2):e0007466. doi: 10.1371/journal.pntd.0007466. eCollection 2020 Feb. PMID: 32092073
    15. VEGFA variants as prognostic markers for the retinopathy in pseudoxanthoma elasticum. De Vilder EYG, Hosen MJ, Martin L, De Zaeytijd J, Leroy BP, Ebran JM, Coucke PJ, De Paepe A, Vanakker OM. Clin Genet. 2020 Jul;98(1):74-79. doi: 10.1111/cge.13751. Epub 2020 May 10. PMID: 32270475
    16. COVID-19 and Bangladesh: Challenges and How to Address Them. Anwar S, Nasrullah M, Hosen MJ. Front Public Health. 2020 Apr 30;8:154. doi: 10.3389/fpubh.2020.00154. eCollection 2020. PMID: 32426318
    17. Homology Modeling and Virtual Screening of Proteins Related to PXE and PXE-like Diseases: Insights for Overlapping Metabolites. Naima J, Abir RA, Hosen MJ. Curr Pharm Biotechnol. 2020;21(14):1470-1478. doi: 10.2174/1389201021666200519115032. PMID: 32427083
    18. Umbilical Cord Blood Screening for the Detection of Common Deletional Mutations of α-Thalassemia in Bangladesh. Anwar S, Taslem Mourosi J, Hasan MK, Hosen MJ, Miah MF. Hemoglobin. 2020 May;44(3):201-210. doi: 10.1080/03630269.2020.1784755. Epub 2020 Jul 1. PMID: 32605390
    19. Blueprint of epitope-based multivalent and multipathogenic vaccines: targeted against the dengue and zika viruses. Sarkar B, Ullah MA, Araf Y, Das S, Hosen MJ. J Biomol Struct Dyn. 2020 Aug 8:1-21. doi: 10.1080/07391102.2020.1804456. Online ahead of print. PMID: 32772811
    20. Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approach. Parvez MSA, Karim MA, Hasan M, Jaman J, Karim Z, Tahsin T, Hasan MN, Hosen MJ. Int J Biol Macromol. 2020 Nov 15;163:1787-1797. doi: 10.1016/j.ijbiomac.2020.09.098. Epub 2020 Sep 17. PMID: 32950529
    21. Genetic analysis of SARS-CoV-2 isolates collected from Bangladesh: Insights into the origin, mutational spectrum and possible pathomechanism. Parvez MSA, Rahman MM, Morshed MN, Rahman D, Anwar S, Hosen MJ. Comput Biol Chem. 2020 Nov 4:107413. doi: 10.1016/j.compbiolchem.2020.107413. Online ahead of print. PMID: 33221119
    22. SARS-CoV-2: a new dimension to our understanding of coronaviruses. Araf Y, Faruqui NA, Anwar S, Hosen MJ. Int Microbiol. 2020 Nov 24:1-6. doi: 10.1007/s10123-020-00152-y. Online ahead of print. PMID: 33231780
    23. Genetic and reproductive consequences of consanguineous marriage in Bangladesh. Anwar S, Taslem Mourosi J, Arafat Y, Hosen MJ. PLoS One. 2020 Nov 30;15(11):e0241610. doi: 10.1371/journal.pone.0241610. eCollection 2020. PMID: 33253173
    24. Women's Knowledge, Attitude, and Perceptions Toward COVID-19 in Lower-Middle-Income Countries: A Representative Cross-Sectional Study in Bangladesh. Anwar S, Araf Y, Newaz Khan A, Ullah MA, Hoque N, Sarkar B, Reshad RAI, Islam R, Ali N, Hosen MJ. Front Public Health. 2020 Nov 17;8:571689. doi: 10.3389/fpubh.2020.571689. eCollection 2020. PMID: 33313035
    25. Comprehensive Phylogenetic Analysis of Root-knot Nematodes Predicts Emerging Virulent Species
    26. Evaluation of antioxidant, anti-hemolytic, cytotoxic effects and anti-bacterial activity of selected mangrove plants (Bruguiera gymnorrhiza and Heritiera littoralis) in Bangladesh
    27. Pathogenic variants in the ABCC6 gene are associated with an increased risk for ischemic stroke. De Vilder EYG, Cardoen S, Hosen MJ, Le Saux O, De Zaeytijd J, Leroy BP, De Reuck J, Coucke PJ, De Paepe A, Hemelsoet D, Vanakker OM. Brain Pathol. 2018 Nov;28(6):822-831. doi: 10.1111/bpa.12620. PMID: 29722917
    28. Pathogenic variants in the ABCC6 gene are associated with an increased risk for ischemic stroke.
    29. Hasan MN, Hosen MJ, Thakur PK, Abir RA, Zubaer A, Renkai G, Yoshida M, Ohta H, Lee JM, Kusakabe T, Hirashima A. In vitro screening for inhibitor of cloned Drosophila melanogaster tyramine-?-hydroxylase and docking studies. Int J Biol Macromol. 2016 Dec;93
    30. Mohammad Jakir Hosen, Filip Van Nieuwerburgh, Dieter Deforce, Ludovic Martin, Georges Leftheriotis, Anne De Paepe, Paul Coucke, Olivier Vanakker. Efficiency of exome sequencing for the molecular diagnosis of Pseudoxanthoma elasticum. Journal of Investigative Dermatology 2015, 135: 992-8. A1 Journal. Impact Factor 7.22. Rank 1/58 in Dermatology Journals
    31. De Vilder EY, Mohammad Jakir Hosen, Vanakker Olivier. The ABCC6 Transporter as a paradigm for Networking from an orphan disease to complex disorder. Biomedical Research International 2015, 2015: 648569. A1 Journal. Impact Factor 2.71
    32. Al Mamun MA, Mohammad Jakir Hosen, Islam K, Khatun A, Alam MM, Al-Bari MA. Tridax procumbens flavonoids promote osteoblast differentiation and bone formation. Biological Research 2015, 48: 1-8. A1 Journal. Impact Factor 1.48
    33. Ariana Kariminejad, Bita Bozorgmehr, Abdolhamid Najafi, Abdolhamid Khoshaeen, Maryam Ghalandari, Hossein Njmabadi, Hasan Kariminejad, Olivier Vanakker, Mohammad Jakir Hosen, Fransiska Malfiat, Daniela Quaglino, Ralph Florijn, Arthur Bergen, Raoul Hennekam. Retinis Pigmentosa, Cutis Laxa and Pseudoxanthoma Elasticum-Like Skin Manifestations Associated with GGCX Mutations. Journal of Investigative Dermatology. 2014, 134: 2331-8. A1 Journal. Impact Factor 7.22. Rank 1/58 in Dermatology Journals
    34. Mohammad Jakir Hosen, Paul Coucke, Olivier Le Saux, Anne De Paepe, Olivier Vanakker. Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticum. Orphanet Journal of Rare Disease 2014, 9: 66. A1 Journal. Impact Factor 3.36
    35. Mohammad Jakir Hosen, Abdullah Zubaer, Simrika Thapa, Bijendra Khadka, Anne De Paepe, Olivier Vanakker. Molecular docking simulations provide insights in the substrate binding sites and possible substrate of the ABCC6 transporter. PLoS One 2014, 9: e102779. A1 Journal. Impact Factor 3.23
    36. M. Etienne, Mohammad Jakir Hosen, G. Leftheriotis, J. M. Ebran, E. De Maistre, O. Vanakker, L. Martin. Pseudoxanthome Elastique associe a un digenisme ABCC6/GGCX. Annales de Dermatologie at de Venereologie 2014, 141: S368. A2 Journal. Impact Factor 0.92
    37. Book Chapter: Chapter 25: Calcification: processes, determinants and health impact (2013). Olivier Vanakker, Mohammad Jakir Hosen, Anne De Paepe. Nova Publishers, NY, USA, ISBN: 978-1-62081- 824-4, 261-304.
    38. Olivier Vanakker, Mohammad Jakir Hosen, Anne De Paepe. The ABCC6 transporter: what lessons can be learnt from other ATP-binding cassette transporters? Frontiers in Genetics 2013, 4: 203. Impact Factor Not Applicable Yet
    39. Mohammad Jakir Hosen, Olivier Vanakker, Andy Willaert, Ann Huysseune, Paul Coucke, Anne De Paepe. Zebrafish models for ectopic mineralization disorders: practical issues from morpholino design to post-injection observations. Frontiers in Genetics 2013, 4: 74. Impact Factor Not Applicable Yet
    40. Aexander Janssen*, Mohammad Jakir Hosen*, Philippe Jeannin, Paul Coucke, Anne De Paepe, Olivier Vanakker. Second family with the Boston-type craniosynostosis syndrome: novel mutation and expansion of the clinical spectrum. *Shared first author. American Journal of Medical Genetics A 2013, 161: 2352-2357. A1 Journal. Impact Factor 2.16
    41. Md. Masuder Rahman, Mohammad Jakir Hosen, Md. Hasibur Rahman, Md. Abul Kalam Azad. Bacteriological quality of fresh shrimps of natural and artificial habitats in Khulna District, Bangladesh. International Journal of Biosciences 2012, 2: 61-65
    42. Mohammad Jakir Hosen, Anouck Lamoen, Anne De Paepe, Olivier Vanakker. Histopathology of pseudoxanthoma elasticum and related disorders: histological hallmarks and diagnostic clues. Scientifica Pathology 2012, 2012: 598262. Impact Factor Not Applicable Yet
    43. Mohammad Jakir Hosen, Mohammod Hossain, Joey G. Martinez, Nnette H. Sumaya, Yuanyun Mei, Shrinkhala Manandhar, Giovanni dos Santos and Tom Moens. Effect of bacterivorous and predatory nematodes on macroalgal detritus decomposition. Proceedings of the Pakistan Academy of Sciences 2011, 48: 137-142
    44. Harun Rashid, Iftekhar Ahmad, Md. Salim, Mohammad Jakir Hosen, B. Elora. Effect of feeding on the larval growth and development of silkworm (Bombyx mori L) race: nistrari (M)
    45. Masuder Rahman, Bahanur Rahman, Tanvir Rahman, Ferdousur Rahman Khan, Mohammad Jakir Hosen, M Mukhlesur Rahman and Bytul M Rahman .Patterns of Antimicrobial Resistance and Plasmid Profiles of Escherichia coli Isolates Obtained from Calf, Cattle and Diarrheic Children in Mymensingh – Bangladesh
    46. I. Ahamad, M.S. Rahman, M.J. Uddin, M.J. Hosen, K. Islam, R. Ara and B. Elora. Effect of some integrated pest management (IPM) packages in the prevention of fruit damage caused by brinjal shoot and fruit borer on eggplant
    47. Md. Abdullah Al Mamun, K.M. Hossain, Mohammad Jakir Hosen, Mohammad Salim, Rowshon Ara. Assessment of coliform risk on selected non-alcoholic beverages of Bangladesh
    48. Mohammad Jakir Hosen, Dilara Islam Sarif, Md. Masuder Rahman, Md. Abul Klalam Azad. Contaminaton of coliforms in different paper currency notes of Bangladesh. Pakistan Journal of Biological Science 2006, 9: 868-870

    Conference Proceedings

    1. Mohammad Jakir Hosen Abu Hasnat Mustafa Ruhshan Ahmed Abir. Homology modeling and molecular docking: pragmatic in silico approach to characterize a transporter protein and predict interacting molecules. International Conference on Bioinformatics and Biostatistics for Agriculture Health and Environment, At Rajshahi University

    Teaching

    • Introduction of Genetic Engineering and Biotechnology
    • Cytology
    • Animal Genetics and Breeding
    • Medical and Pharmaceutical Biotechnology
    • Cell signalling
    • Molecular Mechanism of Diseases
    • Advanced Molecular Biology

    Graduate Supervision

    1. Undergraduate: 10 Masters: 7 M. Phil: 1 (On going) PhD: 1 (On going)